Tendon models

Lunatum Biotech offers sophisticated, established, valid, and reproducible in-vitro and in-vivo models for tendon lesions and tendinopathy:

in-vitro:

2D and 3D culture of tendon cells, stem cells, and immune cells, single culture or co-culture system, using cells from various species, including human cells; 

in-vivo:

Tendinopathy/Tendon rupture animal models (rat, rabbit, minipig, sheep):

 chemically induced tendinopathy: 

In the collagenase model, tendinopathy is induced chemically through injection of type I collagenase.

surgically induced tendon lesions:

- The full thickness tenotomy model involves the complete transection and suturing of the achilles tendon, patellar tendon or rotator cuff.

- In the partial width tendon transection model, a partial tear is surgically induced in the achilles tendon, patellar tendon or rotator cuff.

Evaluation:

Lunatum Biotech offers an array of the most widely accepted and meaningful evaluation methods for tendon healing, applying PCR, NGS, Western blotting, ELISA, histology, immunohistochemistry, ultrasound, MRI, IVIS, biomechanical testing, pain assessment, gait analysis and more ...