Osteoarthritis (OA) Models ( rat, rabbit, minipig)
Chemically induced OA:
In the MIA model, OA is induced chemically through intra-articular injection of monoiodoacetate (MIA).
The MMT+MCLT model involves the surgical induction of OA through procedures such as medial meniscal tear (MMT) and medial collateral ligament transection (MCLT).
In the ACLT model, OA is surgically induced through anterior cruciate ligament transection (ACLT).
The ACLT+pMMx model involves the surgical induction of OA through procedures like anterior cruciate ligament transection (ACLT) and partial medial meniscectomy (pMMx).