Bone Regeneration Models
in-vivo
· Critical sized (5mm) defect in a rat model
Test your bone regeneration technology in our highly published rat model.
https://pubmed.ncbi.nlm.nih.gov/16452748/
https://pubmed.ncbi.nlm.nih.gov/23927083/
· Non-critical sized (2mm) defect in a rat model
Evaluation options: x-ray, micro - computer tomography, histology,
biomechanical evaluation
in-vitro
· 2-D in-vitro osteogenic differentiation of MSC’s
· 3-D in-vitro osteogenic differentiation of MSC’s
See Publication: https://pubmed.ncbi.nlm.nih.gov/28054585/
Evaluation options: qPCR, histology
A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer. Gouze J, Gouze E, Palmer G D, Liew VS, Pascher A, Betz OB, Thornhill TS, Evans CH, Grodzinsky AJ, Ghivizzani SC. Arthritis Res Ther. 5(5):R301-9, 2003. https://pubmed.ncbi.nlm.nih.gov/12932294/
Improvement of tendon repair using muscle grafts transduced with TGF-β1 cDNA. Majewski M, Porter R, Betz OB, Betz VM, Clahsen H, Flückiger R, Evans CH. Eur Cell Mater. 16:23:94-101, 2012. https://pubmed.ncbi.nlm.nih.gov/22354460/
Ex vivo adenoviral transfer of bone morphogenetic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model. Majewski M, Betz O, Ochsner PE, Liu F, Porter RM, Evans CH. Gene Ther.15(16):1139-46, 2008 https://pubmed.ncbi.nlm.nih.gov/18432278/
Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats. Safi E, Ficklscherer A, Bondarava M, Betz OB, Zhang A, Jansson V, Müller PE.
Joints. 13;6(1):4-9, 2018. https://pubmed.ncbi.nlm.nih.gov/29675500/
Duchenne Muscular Dystrophy Gene Therapy. Saad FA, Saad JF, Siciliano G, Merlini L, Angelini C. Curr Gene Ther. 24(1):17-28, 2024. https://pubmed.ncbi.nlm.nih.gov/36411557/
Gene Therapy for Rare Genetic Diseases. Lundstrom K, Yannaki E, Chou J, Saad FA. Curr Gene Ther. 24(1):4-5, 2024. https://pubmed.ncbi.nlm.nih.gov/36959131/
Gene Therapy for Alzheimer and Parkinson Diseases. Saad JF, Saad FA. Curr Gene Ther. 23(3):163-169, 2023. https://pubmed.ncbi.nlm.nih.gov/37114789/
Gene-activated fat grafts for the repair of spinal cord injury: a pilot study. Betz VM, Sitoci-Ficici KH, Uckermann O, Leipnitz E, Iltzsche A, Thirion C, Salomon M, Zwipp H, Schackert G, Betz OB, Kirsch M. Acta Neurochir (Wien). 158(2):367-78, 2016. https://pubmed.ncbi.nlm.nih.gov/26592254/